Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680471 | 0.81 | TDP1 (0.50) | GRM5MEN1KMT2ACYP2A6CCR1 | |
| SCHEMBL24581364 | 0.81 | CCR1 (0.55) | GRM5MEN1KMT2ACCR1CCR8 | |
| SCHEMBL1298969 | 0.80 | GRM5 (0.58) | GRM5MAPK1DYRK1ACYP2A6TGFBR1 | |
| SCHEMBL28763899 | 0.78 | ALDH1A1 (0.52) | MAPK1MEN1KMT2ADYRK1AHPGD | |
| SCHEMBL13680851 | 0.78 | MAPK1 (0.43) | GRM5MAPK1DYRK1AHPGDPDE10A | |
| SCHEMBL13680499 | 0.78 | MAPK1 (0.51) | MAPK1MEN1KMT2ADYRK1AKDM4E | |
| SCHEMBL13680669 | 0.78 | GRM5 (0.49) | GRM5MEN1KMT2ACYP2A6CCR1 | |
| SCHEMBL11041168 | 0.78 | MAPK1 (0.59) | MAPK1MEN1KMT2ADYRK1AKDM4E | |
| SCHEMBL13680584 | 0.77 | GABRG2 (0.53) | GRM5MAPK1CYP2A6CCR1CCR8 | |
| SCHEMBL118090 | 0.77 | P2RX7 (0.59) | GRM5MAPK1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |