Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.51 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | CCR8 | P51685 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CCNH | P51946 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15859041 | 0.80 | CCR1 (0.54) | KDRCCR1CCR8MAPK14CYP2A6 | |
| SCHEMBL13680693 | 0.77 | CCR1 (0.50) | KDRCCR1CCR8MAPK14CYP2A6 | |
| SCHEMBL2865766 | 0.75 | KDR (0.59) | KDRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL6169965 | 0.75 | KDR (0.46) | KDRCCR1CCR8CDK7MAPK14 | |
| SCHEMBL6169974 | 0.75 | KDR (0.46) | KDRCCR1CCR8CCNT1CCNA2 | |
| SCHEMBL13680698 | 0.74 | CCR1 (0.47) | KDRCCR1CCR8MAPK14CYP2A6 | |
| SCHEMBL13680692 | 0.74 | DYRK1A (0.56) | KDRCCR1CCR8MAPK14CYP2A6 | |
| SCHEMBL13513650 | 0.74 | KDR (0.66) | KDRCDK2LMNANPC1RAB9A | |
| SCHEMBL6169672 | 0.73 | KDR (0.44) | KDRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL12715402 | 0.73 | CDK2 (0.51) | CCNT1CCNA2CDK2CDK9CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |