Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169974 | 0.79 | KDR (0.46) | KDRCHEK1CDK7KITFLT3 | |
| SCHEMBL13680697 | 0.75 | KDR (0.51) | KDRCDK7CCR1CCR8MEN1 | |
| SCHEMBL5657365 | 0.68 | HSD17B1 (0.33) | CCR1CCR8NPC1 | |
| SCHEMBL15859041 | 0.68 | CCR1 (0.54) | KDRCCR1CCR8MEN1KMT2A | |
| SCHEMBL6169672 | 0.68 | KDR (0.44) | KDRCDK7KITFLT3CDK4 | |
| SCHEMBL13680693 | 0.66 | CCR1 (0.50) | KDRCCR1CCR8NPC1RAB9A | |
| SCHEMBL13680692 | 0.64 | DYRK1A (0.56) | KDRCCR1CCR8MEN1NPC1 | |
| SCHEMBL13680698 | 0.64 | CCR1 (0.47) | KDRCCR1CCR8MAPK14 | |
| SCHEMBL3370926 | 0.64 | MEN1 (0.43) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL7237397 | 0.64 | KDR (1.00) | KDRCHEK1CDK7MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542994-A1 | NOVEL TRIAZOLE AND OXAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITOR | Pfizer Products Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004026863-A1 | NOVEL OXAZOLE AND THIAZOLE COMPOUNDS AS TRANSFORMING GROWTH FACTOR (TGF) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-04-01 | — | — | WO | disclosed |