Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15859041 | 0.82 | CCR1 (0.54) | CCR1CCR8NOS3NOS2MAPK14 | |
| SCHEMBL13681316 | 0.79 | LOXL2 (0.50) | CCR1CCR8NOS3NOS2TGFBR1 | |
| SCHEMBL13680692 | 0.77 | DYRK1A (0.56) | CCR1CCR8NOS3NOS2MAPK14 | |
| SCHEMBL13680697 | 0.77 | KDR (0.51) | CCR1CCR8NOS3NOS2MAPK14 | |
| SCHEMBL13680698 | 0.77 | CCR1 (0.47) | CCR1CCR8NOS3NOS2MAPK14 | |
| SCHEMBL13629651 | 0.74 | ASIC3 (0.48) | BACE1NOS3NOS2NOS1MAPT | |
| SCHEMBL14606354 | 0.74 | CCR1 (0.62) | CCR1CCR8NOS3NOS2MAPK14 | |
| SCHEMBL17889606 | 0.73 | MAPK14 (0.61) | CCR1CCR8NOS3NOS2MAPK14 | |
| SCHEMBL31093398 | 0.72 | LMNA (0.48) | BACE1MAPK14NOS1NPC1MAPT | |
| SCHEMBL12775047 | 0.71 | NOS3 (0.74) | CCR1CCR8NOS3NOS2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |