Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680575 | 0.75 | CYP2E1 (0.51) | PDE10AADORA2AADORA1CYP3A4CYP2E1 | |
| SCHEMBL13681060 | 0.74 | NPC1 (0.31) | SMN1; SMN2 | |
| SCHEMBL13680745 | 0.73 | PDE10A (0.46) | PDE10AADORA2AADORA1CYP3A4CYP2E1 | |
| SCHEMBL13680739 | 0.70 | ADORA2A (0.49) | PDE10AADORA2AADORA1CYP3A4CYP2E1 | |
| SCHEMBL5912824 | 0.70 | PDE10A (0.59) | PDE10ACYP3A4CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL18157874 | 0.69 | SMN1; SMN2 (0.55) | PDE10AADORA2AADORA1CYP3A4CYP2E1 | |
| SCHEMBL13680687 | 0.68 | CCR1 (0.55) | ADORA2AADORA1CYP3A4CYP2A6CKS1B | |
| SCHEMBL46324 | 0.67 | MEN1 (0.37) | CYP3A4CYP2A6MEN1KMT2AALDH1A1 | |
| SCHEMBL13680737 | 0.67 | ADORA2A (0.39) | PDE10AADORA2AADORA1CYP3A4CYP2E1 | |
| SCHEMBL19396093 | 0.66 | PDE10A (0.39) | PDE10ACYP3A4CYP2E1CYP2A6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |