Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.56 |
| ▸ | AKT2 | P31751 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559766 | 0.88 | FTO (0.48) | MYCAKT2CHEK1FTOALDH1A1 | |
| SCHEMBL13312231 | 0.87 | CHEK1 (0.50) | MYCAKT2CHEK1FTOMCL1 | |
| SCHEMBL4559764 | 0.79 | MYC (0.50) | MYCAKT2CHEK1FTOALDH1A1 | |
| SCHEMBL24770110 | 0.77 | POLQ (0.57) | AKT2CHEK1FTOKDM4EMCL1 | |
| SCHEMBL31375470 | 0.77 | POLB (0.60) | FTOALDH1A1KDM4ETSHRKMT2A | |
| SCHEMBL14197644 | 0.74 | KDM4E (0.57) | MYCALDH1A1KDM4EUSP2TSHR | |
| SCHEMBL11217790 | 0.74 | MYC (0.69) | MYCALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL13990881 | 0.73 | AKT2 (0.53) | AKT2CHEK1KDM4EMCL1KMT2A | |
| SCHEMBL9512847 | 0.72 | MYC (1.00) | MYCALDH1A1KDM4EUSP2TSHR | |
| SCHEMBL27653254 | 0.72 | BCAT2 (0.53) | MYCAKT2CHEK1FTOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240209002-A1 | METAL ORGANIC FRAMEWORKS | ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY (AU) | 2024-06-27 | — | — | US | disclosed |
| US-20240209397-A1 | Thermally Stable Lipid-Nucleic Acid Molecule Formulations Utilising Metal Organic Framework (MOF) Shells | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) | 2024-06-27 | — | — | US | disclosed |
| US-20240180843-A1 | Thermally Stable Vaccine Formulations Utilising Metal Organic Framework (MOF) Shells | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) | 2024-06-06 | — | — | US | disclosed |
| EP-4360751-A1 | METHOD FOR PRODUCING OF A METAL ORGANIC FRAMEWORK, THE METAL ORGANIC FRAMEWORK OBTAINABLE BY SAID METHOD AND ITS USE | Calistair SAS (FR) | 2024-05-01 | — | — | EP | disclosed |
| US-11840580-B2 | Host-guest metal organic framework systems | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2023-12-12 | — | — | US | disclosed |
| US-20220033425-A1 | METAL ORGANIC FRAMEWORKS AND METHODS OF PREPARATION THEREOF | ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY (AU) | 2022-02-03 | — | — | US | disclosed |
| US-10947321-B2 | Host-guest metal organic framework systems | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2021-03-16 | — | — | US | disclosed |
| US-20170166661-A1 | HOST-GUEST METAL ORGANIC FRAMEWORK SYSTEMS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2017-06-15 | — | — | US | disclosed |
| EP-2595989-B1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2016-07-13 | — | — | EP | disclosed |
| CN-102775430-B | Coordination polymer porous material MAF-X8 and preparing method and application thereof | UNIV SUN YAT SEN | 2015-06-24 | — | — | CN | disclosed |
| US-9051296-B2 | Aryl carboxamide derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2015-06-09 | — | — | US | disclosed |
| US-9051296-B2 | Aryl carboxamide derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2015-06-09 | — | — | US | disclosed |
| CN-102775430-A | Coordination polymer porous material MAF-X8 and preparing method and application thereof | UNIV SUN YAT SEN | 2012-11-14 | — | — | CN | disclosed |
| US-20120232052-A1 | ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2012-09-13 | — | — | US | disclosed |
| US-20120232052-A1 | ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2012-09-13 | — | — | US | disclosed |
| US-8067599-B2 | Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090318428-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | HOFFMANN-LA ROCHE, INC. | 2009-12-24 | — | — | US | disclosed |
| EP-2064213-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008028617-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232052-A1 | ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS | SCN1B, SCN1A, SCN2B | MYC 4672/4885AKT2 3727/4885CHEK1 4685/4885 |
| US-20090318428-A1 | HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS | MAP3K5, MAP3K1, PRKACA | MYC 499/4885AKT2 52/4885CHEK1 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.