Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP2A13 | Q16696 | 3/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184392 | 0.86 | CYP2A13 (0.40) | SLC2A1NPSR1CYP2A13KMT2AALDH1A1 | |
| SCHEMBL16200163 | 0.85 | SLC2A1 (0.46) | SLC2A1NPSR1CYP2A13TGFBR1MAPK13 | |
| SCHEMBL16200193 | 0.83 | SLC2A1 (0.42) | SLC2A1NPSR1CYP2A13TGFBR1MAPK13 | |
| SCHEMBL14044135 | 0.80 | SLC2A1 (0.48) | SLC2A1NPSR1CYP2A13TGFBR1PIK3CA | |
| SCHEMBL13683095 | 0.78 | CA1 (0.38) | LMNAKDM4E | |
| SCHEMBL14044138 | 0.78 | ADORA2A (0.40) | NPSR1CYP2A13HTTSMN1; SMN2KCNH2 | |
| SCHEMBL14044093 | 0.76 | METAP1 (0.36) | KMT2AMEN1LMNAKDM4EMETAP2 | |
| SCHEMBL13683031 | 0.76 | ADORA1 (0.36) | KMT2AMEN1LMNAKDM4EMETAP2 | |
| SCHEMBL16200157 | 0.72 | CYP2A13 (0.43) | SLC2A1NPSR1CYP2A13MAPK13MAPK12 | |
| SCHEMBL16200392 | 0.68 | SLC2A1 (0.47) | SLC2A1NPSR1CYP2A13TGFBR1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324216-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |