Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.38 |
| ▸ | WNT3A | P56704 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200362 | 0.80 | KMT2A (0.42) | KMT2AALDH1A1CES2CES1L3MBTL1 | |
| SCHEMBL13683133 | 0.77 | KMT2A (0.45) | KMT2AALDH1A1HSD17B14CES2CES1 | |
| SCHEMBL6919650 | 0.75 | KMT2A (0.46) | KMT2AALDH1A1HSD17B14CES2CES1 | |
| SCHEMBL9197914 | 0.75 | TP53 (0.49) | ALDH1A1L3MBTL1LMNARAB9ANPC1 | |
| SCHEMBL13184261 | 0.72 | BAZ2B (0.49) | KMT2AALDH1A1HSD17B14CES2CES1 | |
| SCHEMBL31369148 | 0.70 | KMT2A (0.75) | KMT2AALDH1A1HSD17B14CES2CES1 | |
| SCHEMBL87791 | 0.70 | KMT2A (0.75) | KMT2AALDH1A1HSD17B14CES2CES1 | |
| SCHEMBL13184427 | 0.70 | KMT2A (0.46) | KMT2AALDH1A1HSD17B14CES2CES1 | |
| SCHEMBL13683180 | 0.69 | KDM4E (0.41) | KMT2AALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL19556155 | 0.69 | L3MBTL1 (0.42) | KMT2AALDH1A1L3MBTL1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |