Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.60 |
| ▸ | MMP2 | P08253 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927964 | 0.85 | NR1H4 (0.58) | RAB9ANPC1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL18114449 | 0.85 | KDM4E (0.67) | MMP13MMP2RAB9ANPC1KDM4E | |
| SCHEMBL5889575 | 0.84 | MMP13 (0.72) | MMP13MMP2RAB9ANPC1KDM4E | |
| SCHEMBL8204629 | 0.84 | MMP13 (0.76) | MMP13MMP2RAB9ANPC1KDM4E | |
| SCHEMBL13684570 | 0.83 | TP53 (0.50) | NPC1NR1H4MEN1KMT2ATP53 | |
| SCHEMBL24601450 | 0.82 | MMP13 (0.72) | MMP13MMP2RAB9ANPC1KDM4E | |
| SCHEMBL8205173 | 0.82 | MMP13 (0.72) | MMP13MMP2RAB9ANPC1KDM4E | |
| SCHEMBL22718539 | 0.81 | MMP13 (0.68) | MMP13MMP2RAB9ANPC1KDM4E | |
| SCHEMBL13684767 | 0.81 | NR1H4 (0.55) | RAB9ANPC1L3MBTL1LMNANR1H4 | |
| SCHEMBL22718574 | 0.80 | MMP13 (0.67) | MMP13MMP2RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522657-B1 | INDOLE DERIVATIVE | TAKEDA PHARMACEUTICAL (JP) | 2016-08-03 | — | — | EP | disclosed |
| US-8642770-B2 | Indole derivative | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-02-04 | — | — | US | disclosed |
| US-20130018073-A1 | INDOLE DERIVATIVE | Takeda Pharmaceuticl Company Limited | 2013-01-17 | — | — | US | disclosed |
| EP-2522657-A1 | INDOLE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018073-A1 | INDOLE DERIVATIVE | MCHR1, MC1R, MCHR2 | MMP13 3111/4885MMP2 3091/4885RAB9A 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.