Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NRP1 | O14786 | 2/20 | 0.90 |
| ▸ | MAPT | P10636 | 10/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.74 |
| ▸ | MEN1 | O00255 | 8/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.63 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29698045 | 0.95 | NRP1 (1.00) | NRP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13684426 | 0.95 | NRP1 (1.00) | NRP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13679622 | 0.85 | NRP1 (0.83) | NRP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13684525 | 0.81 | NRP1 (0.64) | NRP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4410984 | 0.81 | KDM4E (1.00) | NRP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL13684568 | 0.80 | NRP1 (1.00) | NRP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL29977180 | 0.80 | NRP1 (1.00) | NRP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL16782299 | 0.77 | MAPT (1.00) | NRP1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL31578829 | 0.77 | MAPT (1.00) | MAPTKDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL2582594 | 0.77 | MAPT (1.00) | MAPTKDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130041005-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEUROPILIN INHIBITORS, AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF ANGIOGENIC DISORDERS AND CANCERS | TRAGEX PHARMA (FR) | 2013-02-14 | — | — | US | claimed |
| EP-2522341-A1 | Pharmaceutical compositions comprising Neuropilin inhibitors, and their use for the prevention and/or treatment of angiogenic disorders and cancers | Tragex Pharma (FR) | 2012-11-14 | — | — | EP | claimed |
| US-20230000832-A1 | USE OF NEUROPILIN ANTAGONISTS FOR THE TREATMENT OF ENDOMETRIOSIS | ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) (FR) | 2023-01-05 | — | — | US | disclosed |
| US-20230000832-A1 | USE OF NEUROPILIN ANTAGONISTS FOR THE TREATMENT OF ENDOMETRIOSIS | ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) (FR) | 2023-01-05 | — | — | US | disclosed |
| EP-4065224-A1 | USE OF NEUROPILIN ANTAGONISTS FOR THE TREATMENT OF ENDOMETRIOSIS | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2022-10-05 | — | — | EP | disclosed |
| US-20220307021-A1 | A NEUROPILIN ANTAGONIST IN COMBINATION WITH A P38ALPHA-KINASE INHIBITOR FOR THE TREATMENT OF CANCER | UNIVERSITÉ PARIS CITÉ (FR) | 2022-09-29 | — | — | US | disclosed |
| EP-3980012-A1 | A NEUROPILIN ANTAGONIST IN COMBINATION WITH A P38ALPHA-KINASE INHIBITOR FOR THE TREATMENT OF CANCER | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2022-04-13 | — | — | EP | disclosed |
| WO-2021105368-A1 | USE OF NEUROPILIN ANTAGONISTS FOR THE TREATMENT OF ENDOMETRIOSIS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-06-03 | — | — | WO | disclosed |
| WO-2021105368-A1 | USE OF NEUROPILIN ANTAGONISTS FOR THE TREATMENT OF ENDOMETRIOSIS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2021-06-03 | — | — | WO | disclosed |
| WO-2020245210-A1 | A NEUROPILIN ANTAGONIST IN COMBINATION WITH A P38ALPHA-KINASE INHIBITOR FOR THE TREATMENT OF CANCER | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-12-10 | — | — | WO | disclosed |
| WO-2020245210-A1 | A NEUROPILIN ANTAGONIST IN COMBINATION WITH A P38ALPHA-KINASE INHIBITOR FOR THE TREATMENT OF CANCER | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-12-10 | — | — | WO | disclosed |
| EP-2706993-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEUROPILIN INHIBITORS, AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF ANGIOGENIC DISORDERS AND CANCERS | Tragex Pharma (FR) | 2014-03-19 | — | — | EP | disclosed |
| US-20130041005-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEUROPILIN INHIBITORS, AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF ANGIOGENIC DISORDERS AND CANCERS | TRAGEX PHARMA (FR) | 2013-02-14 | — | — | US | disclosed |
| US-20130041005-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEUROPILIN INHIBITORS, AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF ANGIOGENIC DISORDERS AND CANCERS | TRAGEX PHARMA (FR) | 2013-02-14 | — | — | US | disclosed |
| US-20130041005-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEUROPILIN INHIBITORS, AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF ANGIOGENIC DISORDERS AND CANCERS | TRAGEX PHARMA (FR) | 2013-02-14 | — | — | US | disclosed |
| WO-2012156289-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEUROPILIN INHIBITORS, AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF ANGIOGENIC DISORDERS AND CANCERS | TRAGEX PHARMA (FR) | 2012-11-22 | — | — | WO | disclosed |
| WO-2012156289-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEUROPILIN INHIBITORS, AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF ANGIOGENIC DISORDERS AND CANCERS | TRAGEX PHARMA (FR) | 2012-11-22 | — | — | WO | disclosed |
| EP-2522341-A1 | Pharmaceutical compositions comprising Neuropilin inhibitors, and their use for the prevention and/or treatment of angiogenic disorders and cancers | Tragex Pharma (FR) | 2012-11-14 | — | — | EP | disclosed |
| EP-2522341-A1 | Pharmaceutical compositions comprising Neuropilin inhibitors, and their use for the prevention and/or treatment of angiogenic disorders and cancers | Tragex Pharma (FR) | 2012-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230000832-A1 | USE OF NEUROPILIN ANTAGONISTS FOR THE TREATMENT OF ENDOMETRIOSIS | NRP1, PGR, TNFRSF1A | NRP1 1/4885MAPT 4470/4885KDM4E 2845/4885 |
| US-20220307021-A1 | A NEUROPILIN ANTAGONIST IN COMBINATION WITH A P38ALPHA-KINASE INHIBITOR FOR THE TREATMENT OF CANCER | NRP1, MAPK1, MAPKAP1 | NRP1 1/4885MAPT 2086/4885KDM4E 4632/4885 |
| US-20130041005-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING NEUROPILIN INHIBITORS, AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF ANGIOGENIC DISORDERS AND CANCERS | KDR, NRP1, FLT1 | NRP1 2/4885MAPT 2010/4885KDM4E 4580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.