Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | CAPN2 | P17655 | 3/20 | 0.33 |
| ▸ | NAAA | Q02083 | 3/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291299 | 1.00 | GAA (0.35) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL13684914 | 0.94 | GAA (0.33) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL12607418 | 0.91 | GAA (0.38) | GAABACE1CAPN2NAAA | |
| SCHEMBL13685473 | 0.89 | ADAM17 (0.35) | GAACAPN2 | |
| SCHEMBL8291626 | 0.88 | NAAA (0.31) | NAAA | |
| SCHEMBL13684985 | 0.88 | NAAA (0.31) | NAAA | |
| SCHEMBL12607811 | 0.86 | GAA (0.36) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL8291134 | 0.86 | GAA (0.36) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL13685159 | 0.86 | GAA (0.36) | GAAF2F10PRSS1BACE1 | |
| SCHEMBL13684892 | 0.86 | GAA (0.36) | GAAF2F10PRSS1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592419-B2 | Macrocyclic inhibitors of hepatitis C virus NS3-serine protease | SCHERING CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |