Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL13685292 | 0.93 | MAPT (0.44) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL13685400 | 0.93 | RAB9A (0.41) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL2580595 | 0.91 | RAB9A (0.46) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL13685350 | 0.91 | MEN1 (0.39) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL12175406 | 0.91 | ALDH1A1 (0.46) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL12175430 | 0.90 | MAPT (0.38) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL13685359 | 0.89 | MEN1 (0.37) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL2585554 | 0.88 | MEN1 (0.37) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL13685351 | 0.88 | HTR2B (0.39) | ALDH1A1RAB9AMAPTNPC1MEN1 | |
| SCHEMBL2580330 | 0.88 | MAPT (0.36) | ALDH1A1RAB9AMAPTNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680091-B2 | 6-arylalkylamino-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists | ELI LILLY AND COMPANY (US) | 2014-03-25 | — | — | US | claimed |
| EP-1924561-B1 | 6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | LILLY CO ELI (US) | 2012-11-14 | — | — | EP | claimed |