Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898753 | 0.86 | HDAC7 (0.52) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL3359985 | 0.86 | HDAC7 (0.52) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL6954199 | 0.86 | HDAC7 (0.52) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL7438587 | 0.85 | NPC1 (0.50) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL6966437 | 0.82 | HDAC1 (0.58) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL6510657 | 0.82 | HDAC1 (0.58) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL10667117 | 0.81 | HDAC1 (0.56) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL10666776 | 0.81 | HDAC1 (0.56) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL13686537 | 0.81 | HDAC1 (0.53) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL442293 | 0.78 | MMP2 (0.44) | HDAC1HDAC7HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115321-A1 | MIDAZOPYRIMIDINE, IMIDAZOPYRAZINE AND IMIDAZOPYRIDAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2009-09-24 | — | — | WO | disclosed |
| EP-2103614-A1 | Substituted imidazopyrimidine, imidazopyrazine and imidazopyridazine derivatives as melanocortin-4 receptor modulators | Santhera Pharmaceuticals (Schweiz) AG (CH) | 2009-09-23 | — | — | EP | disclosed |