Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13686537 | 0.95 | HDAC1 (0.53) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL30852760 | 0.91 | ALDH1A1 (0.50) | NPC1KMT2A | |
| SCHEMBL1435917 | 0.91 | ALDH1A1 (0.50) | NPC1KMT2A | |
| SCHEMBL6954199 | 0.86 | HDAC7 (0.52) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL3359985 | 0.86 | HDAC7 (0.52) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL7898753 | 0.86 | HDAC7 (0.52) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL13691920 | 0.85 | HDAC1 (0.48) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL9456474 | 0.82 | ALDH1A1 (0.54) | MEN1KMT2A | |
| SCHEMBL6966437 | 0.82 | HDAC1 (0.58) | HDAC1HDAC7HDAC8HDAC3HDAC4 | |
| SCHEMBL6510657 | 0.82 | HDAC1 (0.58) | HDAC1HDAC7HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511271-A1 | THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1992-11-04 | — | — | EP | disclosed |
| EP-0511270-A1 | NEW THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1992-11-04 | — | — | EP | disclosed |
| WO-1991010656-A1 | THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-07-25 | — | — | WO | disclosed |
| WO-1991010657-A1 | NEW THIAZOLE DERIVATIVES | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-07-25 | — | — | WO | disclosed |