Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | BMP4 | P12644 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19173 | 0.93 | — | — | |
| SCHEMBL31338725 | 0.91 | PDE10A (0.45) | PDE10ACDK2SMPD3AXLAPOBEC3A | |
| Hydrochloric Acid SCHEMBL6894527 | 0.91 | PDE10A (0.45) | PDE10ACDK2SMPD3AXLAPOBEC3A | |
| SCHEMBL31674379 | 0.91 | PDE10A (0.45) | PDE10ACDK2SMPD3AXLAPOBEC3A | |
| Pyridine SCHEMBL28190620 | 0.83 | DYRK1A (0.41) | PDE10ACDK2SMPD3AXLAPOBEC3A | |
| Formamide SCHEMBL19611795 | 0.82 | SMPD3 (0.39) | PDE10ACDK2SMPD3AXLAPOBEC3A | |
| M-Xylene SCHEMBL26641909 | 0.79 | ACHE (0.43) | PDE10AAPOBEC3AAPOBEC3GDYRK1ATGFBR1 | |
| SCHEMBL15313356 | 0.77 | ABCG2 (0.48) | PDE10AAPOBEC3G | |
| SCHEMBL4499534 | 0.75 | — | — | |
| SCHEMBL29989948 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067424-B2 | Selective inhibitors for cyclin-dependent kinases | EMORY UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-20100261683-A1 | Selective Inhibitors for Cyclin-Dependent Kinases | EMORY UNIVERSITY | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261683-A1 | Selective Inhibitors for Cyclin-Dependent Kinases | CDK7, CCNK, CDK17 | PDE10A 3045/4885CDK2 5/4885SMPD3 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.