Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2020441 | 0.79 | HSD11B1 (0.53) | ALDH1A1SMN1; SMN2SIGMAR1HTR3EHTR3B | |
| SCHEMBL11150538 | 0.77 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2SIGMAR1HTR3EHTR3B | |
| SCHEMBL13698443 | 0.77 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2SIGMAR1HTR3EHTR3B | |
| SCHEMBL28226906 | 0.77 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2SIGMAR1HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL11157830 | 0.76 | MAPT (0.51) | ALDH1A1SMN1; SMN2SIGMAR1HTR3EHTR3B | |
| SCHEMBL11442075 | 0.74 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2SIGMAR1HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL11458029 | 0.73 | MAPT (0.48) | ALDH1A1SMN1; SMN2SIGMAR1HTR3EHTR3B | |
| SCHEMBL26706278 | 0.71 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2KMT2AMAPTHTR7 | |
| SCHEMBL26706279 | 0.71 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2KMT2AMAPTHTR7 | |
| SCHEMBL12706910 | 0.70 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2SIGMAR1HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090239873-A1 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | BLANCO MIGUEL GARCIA-GUZMAN | 2009-09-24 | — | — | US | disclosed |
| US-7563795-B2 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-07-21 | — | — | US | disclosed |
| US-7563795-B2 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239873-A1 | Phenyl-piperazine derivatives as modulators of muscarinic receptors | CHRM3, CHRM5, CHRM2 | ALDH1A1 2270/4885SMN1; SMN2 4374/4885SIGMAR1 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.