Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | BCHE | P06276 | 5/20 | 0.72 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.68 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.50 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17475575 | 0.91 | TSHR (0.65) | TSHRMAPK1BCHECALM1CAMKK2 | |
| Bromide SCHEMBL21056122 | 0.90 | TSHR (0.63) | TSHRMAPK1BCHECALM1CAMKK2 | |
| SCHEMBL22340700 | 0.84 | TSHR (0.75) | TSHRMAPK1BCHECYP1A2CYP2D6 | |
| SCHEMBL11454505 | 0.83 | TAAR1 (0.57) | TSHRMAPK1BCHECALM1CAMKK2 | |
| SCHEMBL14027662 | 0.83 | CALM1 (0.97) | TSHRMAPK1BCHECALM1CAMKK2 | |
| SCHEMBL14376701 | 0.83 | CALM1 (0.56) | TSHRMAPK1BCHECALM1CAMKK2 | |
| SCHEMBL10276031 | 0.81 | CALM1 (0.62) | TSHRMAPK1BCHECALM1CAMKK2 | |
| SCHEMBL2062287 | 0.81 | CALM1 (0.62) | TSHRMAPK1BCHECALM1CAMKK2 | |
| SCHEMBL14376860 | 0.80 | CALM1 (0.53) | TSHRMAPK1BCHECALM1CAMKK2 | |
| SCHEMBL375111 | 0.80 | KDM4E (0.68) | TSHRMAPK1BCHECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221555-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS | CEPHALON, INC. (US) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221555-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS | ALK, MET, RET | TSHR 1728/4885MAPK1 274/4885BCHE 3315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.