Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.56 |
| ▸ | IL1B | P01584 | 11/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672899 | 0.90 | P2RX7 (0.70) | P2RX7IL1BNPC1 | |
| SCHEMBL12955175 | 0.90 | P2RX7 (0.70) | P2RX7IL1BNPC1 | |
| SCHEMBL11955392 | 0.89 | IL1B (0.51) | P2RX7IL1BCNR1NPC1RAB9A | |
| SCHEMBL13673108 | 0.89 | IL1B (0.51) | P2RX7IL1BCNR1NPC1RAB9A | |
| SCHEMBL1019587 | 0.88 | IL1B (0.65) | P2RX7IL1B | |
| SCHEMBL1020224 | 0.88 | P2RX7 (0.56) | P2RX7IL1BCNR2CNR1NPC1 | |
| SCHEMBL1019692 | 0.88 | IL1B (0.65) | P2RX7IL1B | |
| SCHEMBL1021245 | 0.88 | P2RX7 (0.56) | P2RX7IL1BCNR2CNR1NPC1 | |
| SCHEMBL1018199 | 0.88 | P2RX7 (0.56) | P2RX7IL1BCNR2CNR1NPC1 | |
| SCHEMBL1020461 | 0.88 | P2RX7 (0.56) | P2RX7IL1BCNR2CNR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105164-A1 | Novel P2X7R antagonists and their use | Affectis Pharmaceuticals AG (DE) | 2009-09-30 | — | — | EP | disclosed |