Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10655501 | 0.87 | GAA (0.42) | GAAALDH1A1POLBMEN1KMT2A | |
| SCHEMBL10193355 | 0.87 | ALDH1A1 (0.46) | GAAALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL1093920 | 0.84 | ALDH1A1 (0.65) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL22450720 | 0.84 | PTGER4 (0.52) | GAAALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL29165493 | 0.84 | MAPT (0.47) | GAAALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL22122327 | 0.84 | GAA (0.52) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL16619808 | 0.81 | GAA (0.50) | GAAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1785990 | 0.81 | BCHE (0.57) | ALDH1A1POLBKDM4E | |
| SCHEMBL6640766 | 0.80 | POLB (0.49) | ALDH1A1POLBKDM4EMAPTABCC2 | |
| SCHEMBL6640689 | 0.80 | POLB (0.46) | ALDH1A1POLBKDM4EMAPTABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105164-A1 | Novel P2X7R antagonists and their use | Affectis Pharmaceuticals AG (DE) | 2009-09-30 | — | — | EP | disclosed |