Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 8/20 | 0.45 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6643859 | 0.87 | ABCC2 (0.41) | POLBALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL6640766 | 0.86 | POLB (0.49) | POLBALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL6641148 | 0.84 | ALDH1A1 (0.44) | ALDH1A1NPC1MAPTRAB9ALMNA | |
| SCHEMBL6644618 | 0.84 | KRAS (0.45) | ALDH1A1NPC1MAPTRAB9ALMNA | |
| SCHEMBL6643853 | 0.84 | BCHE (0.42) | ALDH1A1NPC1MAPTRAB9ALMNA | |
| SCHEMBL6642939 | 0.84 | BCHE (0.63) | BCHEACHE | |
| SCHEMBL13132155 | 0.83 | NPC1 (0.54) | POLBALDH1A1NPC1MAPTRAB9A | |
| Formaldehyde SCHEMBL27548620 | 0.83 | POLB (0.47) | POLBALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL13699783 | 0.80 | GAA (0.54) | POLBALDH1A1MAPTLMNAHTT | |
| SCHEMBL6641684 | 0.80 | BCHE (0.65) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109813-B1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RES LTD (GB) | 2004-08-11 | — | — | EP | disclosed |
| US-6433175-B1 | ANTISEROTONINE AGENTS | VERNALIS RESEARCH LIMITED (GB) | 2002-08-13 | — | — | US | disclosed |
| EP-1109813-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012510-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |