Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4280633 | 0.95 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBS1PR1S1PR3KDM4E | |
| SCHEMBL4270743 | 0.95 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBS1PR1S1PR3KDM4E | |
| SCHEMBL13701424 | 0.93 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBS1PR1S1PR3KDM4E | |
| SCHEMBL4280889 | 0.92 | S1PR1 (0.42) | SMN1; SMN2POLBS1PR1S1PR3KDM4E | |
| SCHEMBL4285247 | 0.91 | SMN1; SMN2 (0.40) | SMN1; SMN2POLBS1PR1S1PR3KDM4E | |
| SCHEMBL4271351 | 0.91 | S1PR1 (0.41) | SMN1; SMN2POLBS1PR1S1PR3KDM4E | |
| SCHEMBL4275745 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBS1PR1S1PR3KDM4E | |
| SCHEMBL20052038 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBS1PR1S1PR3KDM4E | |
| SCHEMBL4279400 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBS1PR1S1PR3KDM4E | |
| SCHEMBL34465316 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBS1PR1S1PR3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637559-B2 | Oxazole compound and pharmaceutical composition | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-01-28 | — | — | US | disclosed |
| US-20090221586-A1 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221586-A1 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | PDE3B, PDE4A, PDE3A | SMN1; SMN2 3069/4885POLB 2310/4885S1PR1 964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.