Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.38 |
| ▸ | WNT3A | P56704 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4269874 | 0.96 | KDM4E (0.41) | SMN1; SMN2POLBLMNAKDM4EHSD17B10 | |
| SCHEMBL4280633 | 0.95 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBLMNAKDM4EHSD17B10 | |
| SCHEMBL4270743 | 0.94 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBLMNAKDM4EHSD17B10 | |
| SCHEMBL13701424 | 0.94 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBLMNAKDM4EHSD17B10 | |
| SCHEMBL34465316 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBLMNAKDM4EHSD17B10 | |
| SCHEMBL4279400 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBLMNAKDM4EHSD17B10 | |
| SCHEMBL4275745 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBLMNAKDM4EHSD17B10 | |
| SCHEMBL13701431 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2POLBLMNAKDM4EHSD17B10 | |
| SCHEMBL4280787 | 0.91 | KDM4E (0.45) | SMN1; SMN2LMNAKDM4EHSD17B10MAPT | |
| SCHEMBL4269917 | 0.91 | KDM4E (0.42) | SMN1; SMN2LMNAKDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46792-E1 | Oxazole compound and pharmaceutical composition | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-04-17 | — | — | US | disclosed |
| US-RE46792-E1 | Oxazole compound and pharmaceutical composition | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-04-17 | — | — | US | disclosed |