Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | FDPS | P14324 | 2/20 | 0.58 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TTR | P02766 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28033690 | 0.90 | EPHX2 (0.67) | KDM4EKMT2AALDH1A1NFE2L2HPGD | |
| SCHEMBL13704187 | 0.90 | KDM4E (0.65) | KDM4ESMN1; SMN2KMT2AALDH1A1NFE2L2 | |
| SCHEMBL13704189 | 0.86 | KMT2A (0.71) | KDM4ESMN1; SMN2KMT2AALDH1A1NFE2L2 | |
| SCHEMBL4326745 | 0.85 | KDM4E (0.60) | KDM4ESMN1; SMN2KMT2AALDH1A1NFE2L2 | |
| SCHEMBL13704428 | 0.85 | KDM4E (0.60) | KDM4ESMN1; SMN2KMT2AALDH1A1NFE2L2 | |
| SCHEMBL12221841 | 0.85 | KDM4E (0.78) | KDM4ESMN1; SMN2KMT2AALDH1A1NFE2L2 | |
| SCHEMBL13704177 | 0.85 | HTR1A (0.74) | KDM4ESMN1; SMN2KMT2AALDH1A1NFE2L2 | |
| SCHEMBL2997672 | 0.83 | KDM4E (0.58) | KDM4ESMN1; SMN2KMT2AALDH1A1NFE2L2 | |
| SCHEMBL2997666 | 0.83 | KDM4E (0.58) | KDM4ESMN1; SMN2KMT2AALDH1A1NFE2L2 | |
| SCHEMBL26932284 | 0.82 | JUN (0.62) | KDM4ESMN1; SMN2KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585997-B2 | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof | CHESTERFORD ENTERPRISES LIMITED (KY) | 2009-09-08 | — | — | US | disclosed |
| US-7585997-B2 | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof | CHESTERFORD ENTERPRISES LIMITED (KY) | 2009-09-08 | — | — | US | disclosed |