Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477192 | 0.76 | BRAF (0.54) | BRAFALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13708307 | 0.69 | MELK (0.54) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL4489057 | 0.66 | MELK (0.45) | BRAFALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL4478646 | 0.65 | CFTR (0.51) | BRAFALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL5232976 | 0.63 | SMN1; SMN2 (1.00) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL3419606 | 0.63 | MEN1 (0.64) | BRAFALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL15183729 | 0.63 | RAB9A (1.00) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL3016097 | 0.62 | CA12 (0.52) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL3279549 | 0.62 | MEN1 (0.80) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4471882 | 0.61 | MELK (0.49) | ALDH1A1MAPTPOLBLMNAMELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |