Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.32 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13708608 | 0.93 | SCN5A (0.34) | SCN5ASCN9ABACE1SLC9A1HTR6 | |
| SCHEMBL6275044 | 0.89 | BACE1 (0.34) | BACE1SLC9A1SLC9A5HTR6ATM | |
| SCHEMBL13079029 | 0.89 | BACE1 (0.34) | BACE1SLC9A1SLC9A5HTR6ATM | |
| SCHEMBL13708601 | 0.87 | HTR2B (0.41) | SCN5ASCN9ABACE1SLC9A1HTR6 | |
| SCHEMBL13708560 | 0.84 | CACNA1B (0.35) | BACE1SLC9A1SLC9A5CNR2ALDH1A1 | |
| SCHEMBL13708583 | 0.84 | SLC9A1 (0.35) | BACE1SLC9A1CNR2HTR6 | |
| SCHEMBL4460047 | 0.82 | SCN5A (0.35) | SCN5ASCN9ACNR2KCNH2ALDH1A1 | |
| SCHEMBL4469069 | 0.82 | SCN5A (0.35) | SCN5ASCN9ACNR2KCNH2ALDH1A1 | |
| SCHEMBL4460053 | 0.82 | SCN5A (0.35) | SCN5ASCN9ACNR2KCNH2ALDH1A1 | |
| SCHEMBL13708603 | 0.82 | HTR2B (0.38) | SCN5ASCN9ABACE1SLC9A1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589117-B2 | Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-09-15 | — | — | US | disclosed |
| US-7589117-B2 | Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-09-15 | — | — | US | disclosed |