Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1060628 | 0.91 | SMO (0.54) | SMOLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL10314633 | 0.89 | SMO (0.49) | SMOLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL1061866 | 0.89 | SMO (0.54) | SMOLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL10314543 | 0.86 | LMNA (0.47) | SMOLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL10314568 | 0.85 | MEN1 (0.51) | LMNAMEN1KMT2AALDH1A1GAA | |
| SCHEMBL17677384 | 0.82 | SMO (0.47) | SMOLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL10314495 | 0.82 | SMO (0.68) | SMOLMNAALDH1A1POLB | |
| SCHEMBL1057633 | 0.81 | SMO (0.66) | SMOLMNAHSD17B10 | |
| SCHEMBL10314582 | 0.81 | SMO (0.54) | SMOLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL12962850 | 0.80 | SMO (0.54) | SMOLMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |