Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1060628 | 0.91 | SMO (0.54) | SMOLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL1060942 | 0.89 | SMO (0.58) | SMONPC1RAB9AALDH1A1NPSR1 | |
| SCHEMBL1061384 | 0.85 | LMNA (0.47) | SMOLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL1058238 | 0.84 | LMNA (0.49) | LMNANPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL1062416 | 0.84 | SMO (0.56) | SMOLMNAALDH1A1NPSR1MEN1 | |
| SCHEMBL1061569 | 0.83 | LMNA (0.46) | SMOLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL1061866 | 0.83 | SMO (0.54) | SMOLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL10314582 | 0.82 | SMO (0.54) | SMOLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL13708882 | 0.82 | SMO (0.51) | SMOLMNANPC1RAB9AALDH1A1 | |
| SCHEMBL17677382 | 0.80 | PDE4B (0.47) | SMOLMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-B1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2016-04-13 | — | — | EP | disclosed |