Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513701 | 0.88 | CHRM1 (0.41) | CHRM2CHRM1CHRM3HDAC1PREP | |
| SCHEMBL4521161 | 0.84 | CHRM2 (0.38) | CHRM2CHRM1CHRM3HDAC1PREP | |
| SCHEMBL4513186 | 0.83 | MEN1 (0.38) | CHRM2CHRM1CHRM3HDAC1PREP | |
| SCHEMBL13394929 | 0.81 | CHRM2 (0.38) | CHRM2CHRM1CHRM3HDAC1HSD11B1 | |
| SCHEMBL13394774 | 0.81 | CHRM2 (0.38) | CHRM2CHRM1CHRM3HDAC1HSD11B1 | |
| SCHEMBL4515301 | 0.81 | PDK2 (0.40) | CHRM2CHRM1CHRM3HDAC1PREP | |
| SCHEMBL4519627 | 0.81 | GPR119 (0.47) | CHRM2CHRM1CHRM3PREPHSD11B1 | |
| SCHEMBL5090969 | 0.74 | SLC9A1 (0.38) | CHRM2CHRM1CHRM3FFAR2 | |
| SCHEMBL13998575 | 0.74 | SLC9A1 (0.38) | CHRM2CHRM1CHRM3FFAR2 | |
| SCHEMBL3168339 | 0.72 | CHRM2 (0.41) | CHRM2CHRM1CHRM3HDAC1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589104-B2 | Tricyclic-bridged piperidinyline derivatives as §-opioid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2009-09-15 | — | — | US | disclosed |