Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 6/20 | 0.34 |
| ▸ | HTR2A | P28223 | 6/20 | 0.34 |
| ▸ | DRD3 | P35462 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476805 | 0.91 | MAPT (0.46) | MAOBMITFALDH1A1MAPTTHRB | |
| SCHEMBL13638727 | 0.79 | MAPK11 (0.41) | — | |
| SCHEMBL4474220 | 0.77 | MAPT (0.46) | ALDH1A1MAPT | |
| SCHEMBL4468052 | 0.76 | MAPT (0.48) | ALDH1A1MAPT | |
| SCHEMBL4477182 | 0.72 | MAPT (0.51) | ALDH1A1MAPT | |
| SCHEMBL4471831 | 0.72 | MAPT (0.48) | ALDH1A1MAPT | |
| SCHEMBL4475799 | 0.71 | ALDH1A1 (0.47) | ALDH1A1MAPT | |
| SCHEMBL4472094 | 0.70 | MAPT (0.51) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL4469147 | 0.70 | ALDH1A1 (0.44) | ALDH1A1MAPT | |
| SCHEMBL4468120 | 0.70 | MAPT (0.45) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585859-B2 | PDE4B inhibitors and uses therefor | PLEXXIKON, INC. (US) | 2009-09-08 | — | — | US | disclosed |