Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4517023 | 0.85 | ROCK2 (0.61) | SMN1; SMN2HTTROCK2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4511190 | 0.84 | ROCK2 (0.62) | SMN1; SMN2HTTROCK2MEN1KMT2A | |
| SCHEMBL4527276 | 0.83 | ROCK2 (0.51) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL4513943 | 0.82 | ROCK2 (0.50) | SMN1; SMN2HSD17B10HPGDALDH1A1MAPK1 | |
| SCHEMBL4525552 | 0.81 | KMT2A (0.63) | SMN1; SMN2ALDH1A1TSHRMAPK1ROCK2 | |
| SCHEMBL4520669 | 0.81 | ROCK2 (0.64) | HSD17B10HPGDALDH1A1ALOX15MAPK1 | |
| SCHEMBL4521216 | 0.81 | ROCK2 (0.55) | SMN1; SMN2HTTROCK2MEN1KMT2A | |
| SCHEMBL4517385 | 0.81 | ROCK2 (0.61) | SMN1; SMN2HSD17B10HPGDALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL4517367 | 0.81 | KMT2A (0.61) | SMN1; SMN2ALDH1A1TSHRMAPK1ROCK2 | |
| SCHEMBL4519239 | 0.81 | ROCK2 (0.57) | SMN1; SMN2ALDH1A1HTTROCK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | disclosed |
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | disclosed |
| WO-2007042321-A2 | KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233960-A1 | Kinase Inhibitors | ROCK1, MAP3K1, MAP3K11 | SMN1; SMN2 3162/4885HSD17B10 2684/4885HPGD 1950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.