Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | TP53 | P04637 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158019 | 0.89 | POLB (0.70) | KDM4EPOLBHPGDMAPTTP53 | |
| SCHEMBL3814598 | 0.83 | TP53 (0.52) | KDM4EPOLBHPGDMAPTTP53 | |
| SCHEMBL2158542 | 0.82 | KDM4E (0.85) | KDM4EPOLBHPGDMAPTTP53 | |
| SCHEMBL2158389 | 0.80 | KDM4E (0.73) | KDM4EPOLBHPGDMAPTTP53 | |
| SCHEMBL1406017 | 0.79 | POLB (0.71) | KDM4EPOLBHPGDMAPTTP53 | |
| SCHEMBL13715867 | 0.78 | KDM4E (0.70) | KDM4EPOLBHPGDMAPTTP53 | |
| SCHEMBL5368759 | 0.78 | MAPT (1.00) | KDM4EPOLBHPGDMAPTTP53 | |
| SCHEMBL7057264 | 0.78 | MAPT (0.80) | KDM4EPOLBHPGDMAPTTP53 | |
| SCHEMBL14103873 | 0.77 | ALDH1A1 (0.70) | KDM4EPOLBHPGDMAPTALDH1A1 | |
| SCHEMBL7054758 | 0.77 | KDM4E (0.70) | KDM4EPOLBHPGDMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401825-B1 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS FOR FLAVIVIRUS INFECTION | VIROCHEM PHARMA INC (CA) | 2009-08-05 | — | — | EP | disclosed |