Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.55 |
| ▸ | PRKCG | P05129 | 5/20 | 0.55 |
| ▸ | PRKCB | P05771 | 5/20 | 0.55 |
| ▸ | PRKCA | P17252 | 5/20 | 0.55 |
| ▸ | PRKCH | P24723 | 5/20 | 0.55 |
| ▸ | PRKCI | P41743 | 5/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.55 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.55 |
| ▸ | PRKACA | P17612 | 4/20 | 0.55 |
| ▸ | PRKACG | P22612 | 4/20 | 0.55 |
| ▸ | PRKACB | P22694 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727733 | 0.83 | PRKD3 (0.61) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL7317242 | 0.81 | PRKD3 (0.61) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL2909119 | 0.75 | PRKD3 (0.69) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL2908388 | 0.75 | PRKD3 (0.57) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL9542920 | 0.74 | PRKD3 (0.69) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL10986783 | 0.74 | PRKD3 (0.61) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL190414 | 0.73 | ROCK2 (1.00) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL20644189 | 0.73 | ROCK2 (1.00) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL7318883 | 0.73 | PRKD3 (0.60) | ROCK2ROCK1PRKD3PRKCGPRKCB | |
| SCHEMBL17946426 | 0.73 | ROCK2 (1.00) | ROCK2ROCK1PRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572913-B2 | Inhibitors of Rho kinase; N-Benzyloxycarbonyl-4-[N''-(tert-butyloxycarbonyl)hydrazino]piperidine; 4-{[N''-(tert-butyloxycarbonyl)-N'-(1'-propyl)]hydrazino}piperidine | BIOAXONE THERAPEUTIQUE INC. (CA) | 2009-08-11 | — | — | US | disclosed |
| US-7572913-B2 | Inhibitors of Rho kinase; N-Benzyloxycarbonyl-4-[N''-(tert-butyloxycarbonyl)hydrazino]piperidine; 4-{[N''-(tert-butyloxycarbonyl)-N'-(1'-propyl)]hydrazino}piperidine | BIOAXONE THERAPEUTIQUE INC. (CA) | 2009-08-11 | — | — | US | disclosed |