Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 6/20 | 0.69 |
| ▸ | PRKCZ | Q05513 | 6/20 | 0.69 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.69 |
| ▸ | PRKCG | P05129 | 5/20 | 0.69 |
| ▸ | PRKCB | P05771 | 5/20 | 0.69 |
| ▸ | PRKCA | P17252 | 5/20 | 0.69 |
| ▸ | PRKCH | P24723 | 5/20 | 0.69 |
| ▸ | PRKCI | P41743 | 5/20 | 0.69 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.69 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.69 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.69 |
| ▸ | PRKACA | P17612 | 5/20 | 0.69 |
| ▸ | PRKACG | P22612 | 4/20 | 0.69 |
| ▸ | PRKACB | P22694 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10986783 | 0.84 | PRKD3 (0.61) | PRKD3PRKCZPRKCDPRKCGPRKCB | |
| SCHEMBL10986347 | 0.84 | PRKD3 (0.60) | PRKD3PRKCZPRKCDPRKCGPRKCB | |
| SCHEMBL13186235 | 0.82 | PRKCD (1.00) | PRKD3PRKCZPRKCDPRKCGPRKCB | |
| SCHEMBL29968723 | 0.82 | PRKCD (1.00) | PRKD3PRKCZPRKCDPRKCGPRKCB | |
| SCHEMBL190590 | 0.82 | PRKCD (1.00) | PRKD3PRKCZPRKCDPRKCGPRKCB | |
| SCHEMBL23951537 | 0.81 | PRKD3 (0.81) | PRKD3PRKCZPRKCDPRKCGPRKCB | |
| SCHEMBL7810730 | 0.81 | ROCK2 (0.69) | PRKD3PRKCZPRKCDPRKCGPRKCB | |
| Hydrochloric Acid SCHEMBL1064436 | 0.81 | PRKCD (1.00) | PRKD3PRKCZPRKCDPRKCGPRKCB | |
| Hydrochloric Acid SCHEMBL15093619 | 0.81 | PRKCD (1.00) | PRKD3PRKCZPRKCDPRKCGPRKCB | |
| Hydrochloric Acid SCHEMBL6414754 | 0.81 | PRKCD (1.00) | PRKD3PRKCZPRKCDPRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479386-A1 | Use of isoquinoline-derivatives for treating and preventing pigmentary disorders | Switch Biotech Aktiengesellschaft (DE) | 2004-11-24 | — | — | EP | claimed |
| US-6403590-B1 | Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia | ALCON LABORATORIES, INC. | 2002-06-11 | — | — | US | claimed |
| JP-58121279-A | — | — | None | — | — | JP | disclosed |
| EP-0956865-B2 | MEDICINES COMPRISING Rho KINASE INHIBITOR | MITSUBISHI TANABE PHARMA CORP (JP) | 2010-08-18 | — | — | EP | disclosed |
| US-20090036465-A1 | COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION | UNITED THERAPEUTICS CORPORATION | 2009-02-05 | — | — | US | disclosed |
| WO-2008049000-A2 | COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION | UNITED THERAPEUTICS CORPORATION (US) | 2008-04-24 | — | — | WO | disclosed |
| EP-0956865-B1 | MEDICINES COMPRISING Rho KINASE INHIBITOR | MITSUBISHI PHARMA CORP (JP) | 2007-04-18 | — | — | EP | disclosed |
| US-6906061-B2 | Pharmaceutical agent containing Rho kinase inhibitor | MITSUBISHI PHARMA CORPORATION (JP) | 2005-06-14 | — | — | US | disclosed |
| EP-1479386-A1 | Use of isoquinoline-derivatives for treating and preventing pigmentary disorders | Switch Biotech Aktiengesellschaft (DE) | 2004-11-24 | — | — | EP | disclosed |
| WO-2004062666-A2 | USE OF RHO-KINASE INHIBITORRS FOR TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | UNIVERSITY COLLEGE LONDON (GB) | 2004-07-29 | — | — | WO | disclosed |
| US-20030134775-A1 | Pharmaceutical agent containing Rho kinase inhibitor | UEHATA MASAYOSHI (JP) | 2003-07-17 | — | — | US | disclosed |
| EP-0956865-A1 | MEDICINES COMPRISING Rho KINASE INHIBITOR | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-11-17 | — | — | EP | disclosed |
| US-5747507-A | MYOCARDIAL DISEASE | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1998-05-05 | — | — | US | disclosed |
| EP-0654266-A1 | CARDIAC PROTECTIVE | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-05-24 | — | — | EP | disclosed |
| US-4560755-A | VASODILATOR, HYPOTENSOR | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-12-24 | — | — | US | disclosed |
| US-4525589-A | Isoquinolinesulfonyl derivatives | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1985-06-25 | — | — | US | disclosed |
| EP-0061673-B1 | ISOQUINOLINESULFONYL DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-10-24 | — | — | EP | disclosed |
| US-4456757-A | MUSCLE RELAXANTS, VASODILATORS, HYPOTENSIVE AGENTS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1984-06-26 | — | — | US | disclosed |
| JP-S58121279-A | ISOQUINOLINESULFONYL COMPOUND | ASAHI CHEM IND CO LTD | 1983-07-19 | — | — | JP | disclosed |
| EP-0061673-A1 | Isoquinolinesulfonyl derivatives and process for the preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134775-A1 | Pharmaceutical agent containing Rho kinase inhibitor | ROCK1, RHOA, ARHGDIA | PRKD3 192/4885PRKCZ 334/4885PRKCD 486/4885 |
| US-20090036465-A1 | COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION | ROCK1, ROCK2, RHOA | PRKD3 176/4885PRKCZ 101/4885PRKCD 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.