Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18436160 | 0.82 | MAPT (0.57) | MAPTLRRK2RAB9APOLB | |
| SCHEMBL17128163 | 0.80 | MAPT (0.58) | MAPTLRRK2RAB9AKMT2APOLB | |
| SCHEMBL18436424 | 0.80 | MAPT (0.58) | MAPTLRRK2RAB9AKMT2APOLB | |
| SCHEMBL13105197 | 0.80 | MAPT (0.66) | MAPTLRRK2TSHRRAB9AKMT2A | |
| SCHEMBL13105222 | 0.80 | MAPT (0.66) | MAPTLRRK2TSHRRAB9AKMT2A | |
| SCHEMBL29531915 | 0.77 | MAPT (1.00) | MAPTRAB9APOLB | |
| SCHEMBL18436159 | 0.77 | MAPT (0.51) | MAPTLRRK2RAB9AKMT2A | |
| SCHEMBL11934800 | 0.77 | MAPT (0.51) | MAPTLRRK2RAB9A | |
| SCHEMBL11935563 | 0.77 | MAPT (0.51) | MAPTLRRK2RAB9A | |
| SCHEMBL13438677 | 0.77 | MAPT (0.51) | MAPTLRRK2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1249233-B9 | NPYY5 ANTAGONISTS | SHIONOGI & CO (JP) | 2009-08-05 | — | — | EP | disclosed |
| EP-1249233-B1 | NPYY5 ANTAGONISTS | SHIONOGI & CO (JP) | 2008-08-20 | — | — | EP | disclosed |