Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.33 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3810553 | 0.89 | F11 (0.43) | F11KLKB1ADRA2ANPC1RAB9A | |
| SCHEMBL3817241 | 0.89 | F11 (0.39) | F11KLKB1ADRA2ANPC1RAB9A | |
| SCHEMBL8212864 | 0.86 | F11 (0.38) | F11KLKB1ADRA2ARAB9AALDH1A1 | |
| SCHEMBL13719671 | 0.81 | BCL2 (0.41) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL13719736 | 0.80 | MEN1 (0.36) | NPC1RAB9AALDH1A1L3MBTL1TRPC3 | |
| SCHEMBL13719700 | 0.79 | GRM5 (0.34) | F11KLKB1ALDH1A1TRPC3TRPC6 | |
| SCHEMBL13719858 | 0.79 | PARP1 (0.37) | NPC1RAB9AALDH1A1MAPTPOLB | |
| SCHEMBL1011045 | 0.79 | GRM5 (0.43) | F11KLKB1ADRA2ARAB9AALDH1A1 | |
| SCHEMBL1010236 | 0.79 | GRM5 (0.48) | RAB9AALDH1A1L3MBTL1MAPTPOLB | |
| SCHEMBL13719560 | 0.78 | SPR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |