Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL82833 | 0.84 | ALDH1A1 (0.55) | KDM4EALDH1A1USP2AREGFR | |
| SCHEMBL21996461 | 0.78 | ALDH1A1 (0.49) | KDM4EALDH1A1USP2ARHSD17B10 | |
| SCHEMBL27118917 | 0.78 | ALDH1A1 (0.49) | KDM4EALDH1A1USP2ARLMNA | |
| SCHEMBL1708651 | 0.78 | KDM4E (0.49) | KDM4EALDH1A1USP2NPC1IMPDH2 | |
| SCHEMBL11153594 | 0.78 | NPC1 (0.60) | KDM4EALDH1A1USP2RAB9AMAPK1 | |
| SCHEMBL9672741 | 0.78 | SNCA (0.41) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL13008679 | 0.78 | KDM4E (0.50) | KDM4EALDH1A1MAOBMEN1KMT2A | |
| SCHEMBL2596413 | 0.77 | ALDH1A1 (0.45) | KDM4EALDH1A1USP2ARMAPK1 | |
| SCHEMBL1511834 | 0.76 | ALDH1A1 (0.60) | KDM4EALDH1A1USP2PGRAR | |
| SCHEMBL9721882 | 0.76 | ALDH1A1 (0.50) | KDM4EALDH1A1USP2HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617227-B2 | Process of preparing a quinazoline derivative | SCINOPHARM (CHANGSHU) PHARMACEUTICALS, LTD. (CN) | 2017-04-11 | — | — | US | disclosed |
| US-9617227-B2 | Process of preparing a quinazoline derivative | SCINOPHARM (CHANGSHU) PHARMACEUTICALS, LTD. (CN) | 2017-04-11 | — | — | US | disclosed |
| US-20160200688-A1 | Process of Preparing a Quinazoline Derivative | SCIANDA (CHANGSHU) PHARMACEUTICALS, LTD. (CN) | 2016-07-14 | — | — | US | disclosed |
| US-20160200688-A1 | Process of Preparing a Quinazoline Derivative | SCIANDA (CHANGSHU) PHARMACEUTICALS, LTD. (CN) | 2016-07-14 | — | — | US | disclosed |
| WO-2015188318-A1 | PROCESS FOR PREPARING QUINAZOLINE DERIVATIVE | SCINOPHARM (CHANGSHU) PHARMACEUTICALS, LTD. (CN) | 2015-12-17 | — | — | WO | disclosed |
| EP-1546119-B1 | PROCESS FOR THE PREPARATION OF 4- (3'CHLORO-4'-FLUOROANILINO) -7-METHOXY-6- (3-MORPHOLINOPROPOXY) QUINAZOLINE | ASTRAZENECA AB (SE) | 2009-08-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200688-A1 | Process of Preparing a Quinazoline Derivative | ABL1, EGFR, KRAS | KDM4E 3859/4885ALDH1A1 2355/4885USP2 4395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.