Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.39 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512393 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL13723607 | 0.82 | SMN1; SMN2 (0.35) | SMN1; SMN2KMT2A | |
| SCHEMBL7512408 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL7520459 | 0.75 | KMT2A (0.46) | SMN1; SMN2FAAHKMT2A | |
| SCHEMBL17551463 | 0.74 | ACHE (0.36) | SMN1; SMN2KMT2A | |
| SCHEMBL7527245 | 0.72 | CHRM4 (0.41) | KMT2A | |
| SCHEMBL7528142 | 0.71 | ADAMTS5 (0.40) | SMN1; SMN2RAB9ACYP2C9CYP2C19HTT | |
| SCHEMBL13197107 | 0.71 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL13538207 | 0.71 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 | |
| SCHEMBL15140566 | 0.71 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9AGRIN2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838304-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORP (US) | 2009-08-19 | — | — | EP | disclosed |