Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28005361 | 0.85 | HTR2A (0.34) | CHEK1CCNA2CDK2CCNA1HTR2A | |
| SCHEMBL13522013 | 0.85 | HTR2A (0.41) | CHEK1CCNA2CDK2CCNA1HTR2A | |
| Hydrochloric Acid SCHEMBL9054801 | 0.84 | HTR2A (0.40) | CHEK1CCNA2CDK2CCNA1HTR2A | |
| SCHEMBL15587858 | 0.81 | MAP4K4 (0.41) | HTR2A | |
| SCHEMBL440391 | 0.78 | L3MBTL1 (0.43) | — | |
| SCHEMBL2600249 | 0.76 | HTR2A (0.40) | CHEK1CCNA2CDK2CCNA1HTR2A | |
| Hydrochloric Acid SCHEMBL3131727 | 0.75 | CHRM1 (0.46) | HTR2A | |
| Hydrochloric Acid SCHEMBL3131740 | 0.75 | CHRM1 (0.46) | HTR2A | |
| Hydrochloric Acid SCHEMBL4521825 | 0.75 | HTR2A (0.39) | CHEK1CCNA2CDK2CCNA1HTR2A | |
| Hydrochloric Acid SCHEMBL4229174 | 0.75 | GRM5 (0.40) | CHEK1CCNA2CDK2CCNA1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203737-A1 | Pyrrole Derivatives as Positive Allosteric Modulators of Metabotropic Receptors | ADDEX PHARMA SA (CH) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203737-A1 | Pyrrole Derivatives as Positive Allosteric Modulators of Metabotropic Receptors | GRM5, GRIK5, GRM2 | CHEK1 4548/4885CCNA2 3516/4885CDK2 1407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.