Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.45 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.45 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.45 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 2/20 | 0.45 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13732517 | 0.74 | PDE10A (0.41) | ALOX5APKDM4EMTORPDE10A | |
| SCHEMBL22616998 | 0.73 | HRH3 (0.48) | CHUKCUL4AADORA2AADORA1ADORA3 | |
| SCHEMBL4679581 | 0.73 | CUL4A (0.44) | CHUKCUL4AADORA2AADORA1ADORA3 | |
| SCHEMBL13724515 | 0.72 | MAP4K1 (0.39) | CHUKCUL4ACCNE1CDK2IRAK4 | |
| SCHEMBL5204163 | 0.71 | ADORA3 (0.44) | CHUKCUL4AADORA2AADORA1ADORA3 | |
| SCHEMBL5075232 | 0.70 | CHUK (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CHUK | |
| SCHEMBL5078760 | 0.70 | CHUK (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CHUK | |
| SCHEMBL5075238 | 0.70 | CHUK (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1CHUK | |
| SCHEMBL27948440 | 0.69 | MAP4K1 (0.39) | CHUKCUL4ACCNE2CDK4CCND1 | |
| SCHEMBL4675962 | 0.69 | CHUK (0.42) | CHUKCUL4AADORA2AADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |