Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 6/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.33 |
| ▸ | CDK2 | P24941 | 5/20 | 0.33 |
| ▸ | CDK9 | P50750 | 5/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.33 |
| ▸ | CDK7 | P50613 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.33 |
| ▸ | CCNH | P51946 | 2/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.33 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.32 |
| ▸ | CDK1 | P06493 | 3/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724515 | 0.79 | MAP4K1 (0.39) | MAP4K1CHUKNPY5RCUL4ACCNK | |
| SCHEMBL27948447 | 0.72 | KHK (0.44) | CDK8KDM4EALDH1A1 | |
| SCHEMBL7714582 | 0.71 | LTA4H (0.39) | NPY5RCUL4ACDK9CCNT1CDK8 | |
| SCHEMBL13723671 | 0.69 | GUCY1B2 (0.45) | CHUKCUL4ACDK2CCNE1CCNE2 | |
| SCHEMBL4673206 | 0.69 | NPY5R (0.41) | MAP4K1NPY5RCUL4ACCNKCDK12 | |
| Hydrochloric Acid SCHEMBL5394721 | 0.69 | NPY5R (0.41) | MAP4K1NPY5RCUL4ACCNKCDK12 | |
| SCHEMBL5206837 | 0.67 | FFAR1 (0.42) | CDK9CCNT1CDK8 | |
| SCHEMBL31006839 | 0.67 | NPY5R (0.41) | MAP4K1NPY5RCUL4ACCNKCDK12 | |
| SCHEMBL4673093 | 0.65 | ALDH1A1 (0.55) | NPY5RCUL4AALDH1A1MAPTALOX12 | |
| SCHEMBL3956020 | 0.64 | JAK3 (0.65) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492389-A | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors | ORIGENIS GMBH | 2014-01-01 | — | — | CN | disclosed |