Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27672161 | 0.93 | KDM1A (0.39) | KDM1APLK1APOBEC3GALDH1A1PDE4A | |
| SCHEMBL41241 | 0.93 | KDM1A (0.39) | KDM1APLK1APOBEC3GALDH1A1PDE4A | |
| Phosphine SCHEMBL27662410 | 0.92 | KDM1A (0.38) | KDM1APLK1APOBEC3GALDH1A1PDE4A | |
| Thiourea SCHEMBL29139740 | 0.86 | KDM1A (0.35) | KDM1APLK1APOBEC3GALDH1A1PDE4A | |
| SCHEMBL297038 | 0.84 | — | — | |
| SCHEMBL10616922 | 0.83 | MAPT (0.43) | PLK1APOBEC3GALDH1A1ADORA2ATDP1 | |
| SCHEMBL11581587 | 0.82 | HTT (0.44) | PLK1APOBEC3GALDH1A1ADORA2ATDP1 | |
| Glycine SCHEMBL2322797 | 0.82 | PDE4A (0.35) | KDM1APLK1APOBEC3GALDH1A1PDE4A | |
| Thiouracil SCHEMBL28203909 | 0.82 | TP53 (0.54) | KDM1APLK1APOBEC3GALDH1A1PDE4A | |
| Imidazole SCHEMBL27283840 | 0.81 | TDP1 (0.39) | PLK1APOBEC3GALDH1A1PDE4AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| EP-2699579-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143144-A1 | PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |