Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorphenoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.61 |
| ▸ | DRD3 | P35462 | 5/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.61 |
| ▸ | HTR2A | P28223 | 4/20 | 0.61 |
| ▸ | HTR2C | P28335 | 4/20 | 0.61 |
| ▸ | HTR2B | P41595 | 4/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorphenoxamine SCHEMBL29208 | 0.88 | CHRM2 (0.61) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 | |
| Chlorphenoxamine SCHEMBL125112 | 0.87 | CHRM2 (0.59) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 | |
| Moxastine SCHEMBL6700857 | 0.86 | SLC6A2 (0.62) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 | |
| Chlorphenoxamine SCHEMBL1649036 | 0.86 | CHRM2 (0.62) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 | |
| Clemastine SCHEMBL28193835 | 0.83 | CHRM2 (0.73) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 | |
| Clemastine SCHEMBL4652160 | 0.83 | CHRM2 (0.73) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 | |
| Doxylamine SCHEMBL17558540 | 0.81 | CHRM2 (0.79) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 | |
| Doxylamine SCHEMBL13725455 | 0.80 | CHRM2 (0.73) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 | |
| Moxastine SCHEMBL29281 | 0.80 | CHRM2 (0.71) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 | |
| Diphenhydramine SCHEMBL4064 | 0.78 | SLC6A2 (1.00) | CHRM2SLC6A2SLC6A3CYP2D6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |