Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorphenoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorphenoxamine SCHEMBL29208 | 0.97 | CHRM2 (0.61) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 | |
| Chlorphenoxamine SCHEMBL125112 | 0.95 | CHRM2 (0.59) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 | |
| Moxastine SCHEMBL29281 | 0.87 | CHRM2 (0.71) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 | |
| Chlorphenoxamine SCHEMBL13723924 | 0.86 | CHRM2 (0.61) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 | |
| Clofenetamine SCHEMBL2110100 | 0.82 | CHRM2 (0.54) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 | |
| Embramine SCHEMBL28365 | 0.82 | CHRM2 (0.61) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 | |
| Clofenetamine SCHEMBL4422383 | 0.81 | CHRM2 (0.53) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 | |
| Embramine SCHEMBL1650532 | 0.81 | CHRM2 (0.59) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL2738809 | 0.80 | CHRM2 (0.49) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL10733508 | 0.80 | CHRM2 (0.61) | CHRM2SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846788-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | Akron Molecules AG (AT) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013167743-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | AKRON MOLECULES GMBH (AT) | 2013-11-14 | — | — | WO | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |