Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | NQO1 | P15559 | 4/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.42 |
| ▸ | VKORC1 | Q9BQB6 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tioclomarol SCHEMBL43646 | 0.88 | NQO1 (0.58) | THRBNQO1TOP2ACYP2C9VKORC1 | |
| SCHEMBL1651856 | 0.76 | THRB (0.42) | THRBNQO1TOP2ACYP2C9VKORC1 | |
| Chlorophacinone SCHEMBL4187624 | 0.71 | MEN1 (0.81) | THRBMEN1KMT2AADORA3CHRM1 | |
| Chlorophacinone SCHEMBL29353036 | 0.71 | MEN1 (0.81) | THRBMEN1KMT2AADORA3CHRM1 | |
| Chlorophacinone SCHEMBL29455171 | 0.71 | MEN1 (0.81) | THRBMEN1KMT2AADORA3CHRM1 | |
| Chlorophacinone SCHEMBL11577573 | 0.71 | MEN1 (0.81) | THRBMEN1KMT2AADORA3CHRM1 | |
| Chlorophacinone SCHEMBL18961 | 0.71 | MEN1 (0.81) | THRBMEN1KMT2AADORA3CHRM1 | |
| Chlorophacinone SCHEMBL9356813 | 0.70 | MEN1 (0.79) | THRBMEN1KMT2AADORA3CHRM1 | |
| SCHEMBL1649084 | 0.67 | NQO1 (0.70) | NQO1TOP2ACYP2C9VKORC1MEN1 | |
| SCHEMBL7406235 | 0.66 | CYP2C9 (0.82) | NQO1CYP2C9VKORC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |