Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.39 |
| ▸ | MCHR2 | Q969V1 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3095937 | 0.91 | MC4R (0.54) | MC4RDRD2DRD4DRD3SLC29A1 | |
| SCHEMBL13724004 | 0.89 | HSD17B10 (0.44) | MC4RCYP2D6 | |
| SCHEMBL3088805 | 0.80 | MC4R (0.47) | MC4RCYP2D6 | |
| SCHEMBL13724506 | 0.80 | MC4R (0.46) | MC4R | |
| SCHEMBL13180228 | 0.79 | MC4R (0.48) | MC4RDRD2DRD4DRD3ADORA2A | |
| SCHEMBL3090271 | 0.77 | MC4R (0.72) | MC4R | |
| SCHEMBL3095952 | 0.75 | MC4R (0.76) | MC4R | |
| SCHEMBL13147367 | 0.75 | MC4R (0.73) | MC4R | |
| SCHEMBL14193791 | 0.74 | MC4R (0.72) | MC4R | |
| SCHEMBL3089431 | 0.72 | MC4R (0.71) | MC4RDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590338-B1 | MODULATORS OF MELANOCORTIN RECEPTOR | ORE PHARMACEUTICALS INC (US) | 2009-08-26 | — | — | EP | disclosed |