SCHEMBL13724877

SCHEMBL13724877

CON(C)C(=O)c1ccc(Cl)c(O)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.45
SLC6A3 Q01959 1/20 0.45
HSP90AA1 P07900 3/20 0.44
HSP90AB1 P08238 2/20 0.44
DPP4 P27487 6/20 0.41
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA7 P43166 1/20 0.40
XDH P47989 1/20 0.40
CA9 Q16790 1/20 0.40
CA14 Q9ULX7 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
TPMT P51580 1/20 0.39
CYP1A2 P05177 1/20 0.39
BLM P54132 1/20 0.39
ALDH1A1 P00352 1/20 0.38
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2655175 0.86 SLC6A3 (0.54) MLYCDSLC6A3HSP90AA1HSP90AB1MEN1
SCHEMBL13359302 0.84 CA12 (0.56) MLYCDHSP90AA1HSP90AB1CA12CA1
SCHEMBL4097869 0.83 MLYCD (0.45) MLYCDSLC6A3HSP90AA1HSP90AB1MEN1
SCHEMBL185480 0.82 MEN1 (0.48) MLYCDSLC6A3HSP90AA1HSP90AB1MEN1
SCHEMBL5604944 0.82 CYP1A2 (0.44) MLYCDSLC6A3HSP90AA1HSP90AB1DPP4
SCHEMBL6988786 0.82 MLYCD (0.44) MLYCDSLC6A3HSP90AA1HSP90AB1MEN1
SCHEMBL940787 0.80 STAT3 (0.51) CA12CA1CA2CA7HSD17B10
SCHEMBL760870 0.80 MLYCD (0.49) MLYCDHSP90AA1HSP90AB1CA12CA1
SCHEMBL8988251 0.80 MLYCD (0.45) MLYCDSLC6A3HSP90AA1HSP90AB1MEN1
SCHEMBL1438344 0.79 MLYCD (0.48) MLYCDSLC6A3HSP90AA1HSP90AB1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2702043-A1 INHIBITORS OF INDUCIBLE FORM OF 6-PHOSPHOFRUCTOSE-2-KINASE Exelixis, Inc. (US) 2014-03-05 EP disclosed
WO-2012149528-A1 INHIBITORS OF INDUCIBLE FORM OF 6-PHOSPHOFRUCTOSE-2-KINASE EXELIXIS, INC. (US) 2012-11-01 WO disclosed