Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27783084 | 0.81 | CYP19A1 (0.44) | CYP19A1PRSS1PRSS2PRSS3ELANE | |
| SCHEMBL28206827 | 0.81 | CYP19A1 (0.44) | CYP19A1PRSS1PRSS2PRSS3ELANE | |
| SCHEMBL27684657 | 0.80 | CYP19A1 (0.46) | CYP19A1PRSS1PRSS2PRSS3SLC1A3 | |
| SCHEMBL7782888 | 0.79 | ALPI (0.48) | CYP19A1PRSS1PRSS2PRSS3SLC1A3 | |
| SCHEMBL27502115 | 0.79 | SLC1A3 (0.46) | CYP19A1PRSS1PRSS2PRSS3SLC1A3 | |
| SCHEMBL9048057 | 0.77 | SCN4A (0.50) | CYP19A1PRSS1PRSS2PRSS3SLC1A3 | |
| SCHEMBL8421334 | 0.77 | PRSS1 (0.45) | CYP19A1PRSS1PRSS2PRSS3SLC1A3 | |
| SCHEMBL7709512 | 0.77 | ATM (0.44) | CYP19A1PRSS1PRSS2PRSS3SLC1A3 | |
| SCHEMBL27833901 | 0.76 | CYP19A1 (0.49) | CYP19A1PRSS1PRSS2PRSS3SLC1A3 | |
| SCHEMBL666155 | 0.74 | POLB (0.47) | CYP19A1ELANEALDH1A1MAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111448199-A | Novel highly active amino-thiazole-substituted indole-2-carboxamides having activity against Hepatitis B Virus (HBV) | 艾库里斯有限及两合公司 | 2020-07-24 | — | — | CN | disclosed |
| WO-2012150866-A1 | PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND USES THEREOF | INDUSTRIAL RESEARCH LIMITED (NZ) | 2012-11-08 | — | — | WO | disclosed |