Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61488 | 0.88 | KIF11 (0.46) | ATML3MBTL1CYP19A1SLC1A3ELANE | |
| SCHEMBL27761275 | 0.88 | ATM (0.44) | ATML3MBTL1SLC1A3ELANESLC7A5 | |
| SCHEMBL27867103 | 0.88 | ATM (0.44) | ATML3MBTL1SLC1A3ELANESLC7A5 | |
| SCHEMBL7782885 | 0.87 | ATM (0.45) | ATML3MBTL1SLC1A3ELANEALPI | |
| SCHEMBL7782886 | 0.87 | ATM (0.45) | ATML3MBTL1SLC1A3ELANEALPI | |
| SCHEMBL7782888 | 0.87 | ALPI (0.48) | CYP19A1PRSS1PRSS2PRSS3SLC1A3 | |
| SCHEMBL7782168 | 0.86 | L3MBTL1 (0.44) | ATML3MBTL1PRSS1PRSS2PRSS3 | |
| SCHEMBL7782165 | 0.86 | L3MBTL1 (0.44) | ATML3MBTL1PRSS1PRSS2PRSS3 | |
| SCHEMBL8421334 | 0.86 | PRSS1 (0.45) | ATML3MBTL1CYP19A1PRSS1PRSS2 | |
| SCHEMBL27781916 | 0.85 | ALDH1A1 (0.44) | ATML3MBTL1CYP19A1PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436691-B1 | CONJUGATE WHICH IS SUBSTANTIALLY NON-IMMUNOGENIC IN HUMANS COMPRISING TARGETING MOIETY CAPABLE OF BINDING WITH TUMOR ASSOCIATED ANTIGEN LINKED TO MUTATED FORM OF CARBOXYPEPTIDASE B ENZYME CAPABLE OF CONVERTING PRODRUG INTO ANTICANCER DRUG | ZENECA LIMITED (GB) | 2002-08-20 | — | — | US | disclosed |
| EP-0806964-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-08-14 | — | — | EP | disclosed |
| US-5985281-A | ANTIBODY DIRECTED ENZYME PRODRUG THERAPY (ADEPT) USING A NON-NATURALLY OCCURING MUTANT FORM OF A HOST ENZYME, ESPECIALLY A MUTANT FORM OF RIBONUCLEASE. | ZENECA LIMITED (GB) | 1999-11-16 | — | — | US | disclosed |
| CN-1193278-A | Chemical compounds | ZENECA LTD (GB) | 1998-09-16 | — | — | CN | disclosed |
| EP-0844885-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1998-06-03 | — | — | EP | disclosed |
| EP-0806964-A1 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1997-11-19 | — | — | EP | disclosed |
| WO-1997007769-A2 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1997-03-06 | — | — | WO | disclosed |
| WO-1996020011-A1 | CHEMICAL COMPOUNDS | ZENECA LIMITED (GB) | 1996-07-04 | — | — | WO | disclosed |