SCHEMBL13728314

SCHEMBL13728314

O=C(NCc1ccncc1)c1nc(N[C@@H](Cc2cccc(C(F)(F)F)c2)C(=O)O)nc(O)c1O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SORT1 Q99523 1/20 0.45
NAMPT P43490 2/20 0.43
MLYCD O95822 1/20 0.42
EPHB4 P54760 1/20 0.42
GSK3B P49841 2/20 0.42
PTGER4 P35408 1/20 0.42
ELANE P08246 1/20 0.42
PPARA Q07869 1/20 0.41
VNN1 O95497 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CNR2 P34972 1/20 0.40
KDR P35968 1/20 0.40
TRPV1 Q8NER1 1/20 0.40
MEN1 O00255 1/20 0.40
PLA2G1B P04054 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
GAA P10253 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13727908 0.95 PTGER4 (0.47) MLYCDPTGER4PPARACNR2MEN1
SCHEMBL13728299 0.86 POLB (0.51) MLYCDSMN1; SMN2CNR2MEN1GAA
SCHEMBL13730739 0.86 CA12 (0.41) NAMPTMLYCDCYP1A2CYP3A4CYP2D6
SCHEMBL13728168 0.84 CTSL (0.40) PTGER4PPARACYP1A2CYP3A4CYP2D6
SCHEMBL13729576 0.84 MEN1 (0.47) MEN1KMT2A
SCHEMBL13823958 0.79 GSK3B (0.51) SORT1NAMPTMLYCDEPHB4GSK3B
SCHEMBL15592675 0.76 MLYCD (0.55) MLYCDPTGER4CNR2MEN1PLA2G1B
SCHEMBL13823966 0.75 PTGER4 (0.52) MLYCDPTGER4VNN1CNR2MEN1
SCHEMBL31347370 0.73 MLYCD (0.57) MLYCDPTGER4CNR2MEN1PLA2G1B
SCHEMBL13729117 0.71 MLYCD (0.52) MLYCDPTGER4MEN1PLA2G1BCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012151567-A1 PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2012-11-08 WO disclosed