Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 16/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18035933 | 0.87 | PDE2A (0.60) | PDE2AGAAMAPTHPGDGSK3B | |
| SCHEMBL13727088 | 0.80 | PDE2A (0.65) | PDE2A | |
| SCHEMBL13726218 | 0.79 | KMT2A (0.47) | GAAMAPTHPGDCHEK2 | |
| SCHEMBL1079995 | 0.76 | ALDH1A1 (0.49) | GAAHPGDGSK3BCHEK2 | |
| SCHEMBL14508422 | 0.76 | MAPT (0.64) | GAAMAPTHPGDGSK3B | |
| SCHEMBL29310598 | 0.75 | GAA (0.54) | PDE2AGAAMAPTHPGDGSK3B | |
| SCHEMBL4822785 | 0.74 | GSK3B (0.84) | GAAMAPTHPGDGSK3B | |
| SCHEMBL16868331 | 0.74 | PDE2A (0.85) | PDE2A | |
| SCHEMBL21924751 | 0.74 | PDE2A (0.91) | PDE2A | |
| SCHEMBL16867876 | 0.74 | PDE2A (0.91) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087060-B1 | PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-05-13 | — | — | EP | disclosed |
| WO-2015096651-A1 | PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-07-02 | — | — | WO | disclosed |
| WO-2012151567-A1 | PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2012-11-08 | — | — | WO | disclosed |